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In fact, demand in the Chinese-style neighborhood snack segment is enormous. Shaxian Snacks and Hangzhou Xiaolongbao each have more than 10,000 and 30,000 stores nationwide, respectively. Although Yuanji Foods, with over 4,000 stores (nearly 1,500 in the Yangtze River Delta), ranks among the leaders, most brands in the sector are still mainly mom-and-pop operations, with weak quality control and fragmented supply chains. A comparable listed company in the same category, Babi Food, also focuses on neighborhood breakfast and snack scenarios and has achieved scaled expansion through franchising. However, Babi Food is positioned as more affordable, with an average ticket size of RMB 12–15—well below Yuanji Foods’ roughly RMB 20—while offering a broader product range that includes buns, steamed buns, and other breakfast items. Its supply-chain buildout is also more mature, giving it an edge in gross margin.
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In order to directly assess DNA strands going through the nanopore, two major problems needed solving. The first was that DNA moved too fast to reliably detect; the second was that individual bases still could not be differentiated, just purines and pyrimidines. In 2005, Bayley (who by then had moved to Oxford) made progress on the first issue, working with scientists at the Scripps Institute to slow the template DNA down by adding short “hairpin” structures that partially blocked off the pore. That year, Bayley co-founded Oxford Nanopore Technologies (ONT) to develop the emerging sequencing method. ONT quickly brought together various technologies, licensing IP from the labs of Bayley, Deamer, Branton, and others.
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Later in his life, Geisel said of this partnership: "I was surprised to see him alive. He was surprised to see me in any form."